| Anti-Inflammatory Effects of Chrysanthemum indicum Water Extract in RAW 264.7 Cell as a Whole Plant |
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Kang, Kyoungah |
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Department of Nursing, Kunsan National University, Gunsan, Korea. rallycar@kunsan.ac.kr |
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| Abstract |
PURPOSE
Chrysanthemum indicum (CHI) has been used for edible and medical purposes for a long time in Korea. The purpose of this study was to evaluate the anti-inflammatory effects of CHI water extract in lipopolysaccharides (LPS)-induced RAW 264.7 macrophage cells.
METHODS
To investigate the anti-inflammatory effects on LPS-induced RAW 264.7 macrophage cells, CHI extract as a whole plant was used in this study. RAW 264.7 cells were treated with various concentrations of CHI extract (1, 10, and100 microg/mL). After that Nitric Oxide (NO), inducible nitric oxide synthase (iNOS), interleukin (IL)-1beta, cyclooxygenase (COX)-2 and prostaglandin E2 (PGE2) expression level were measured.
RESULTS
CHI extract significantly suppressed the LPS-induced NO production and decreased the level of iNOS, IL-1beta, COX-2 messenger ribonucleic acid (mRNA) expression and also the down regulation of PGE2 expression in a dose-dependent manner.
CONCLUSION
The present study suggested that CHI extract can be substituted for anti-inflammatory drugs and provide a safe and effective non pharmacological therapeutic approach. |
| Key Words:
Anti-inflammation, Chrysanthemum indicum, RAW 264.7 cell |
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